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Su-Lan Liao, Yen-Chuan Ou, Cheng-Yi Chang, Wen-Ying Chen, Yu-Hsiang Kuan, Wen-Yi Wang, Hung-Chuan Pan and Chun-Jung Chen Diethylmaleate and iodoacetate in combination caused profound cell death in astrocytes Journal of Neurochemistry 127

Article first published online: 20 MAY 2013 | DOI: 10.1111/jnc.12291

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Energy failure and oxidative stress have been implicated in the pathogenesis of ischemia and cell death. Through the application of the glycolytic inhibitor iodoacetate and the glutathione chelator diethylmaleate, we report a potential link between cytosolic phospholipase A2 (cPLA2) activation and energy failure/oxidative stress-induced astrocyte damage involving reactive oxygen species (ROS), signaling through the kinases PKC-α, Src, Raf, and ERK and concurrent elevation of endogenous chelatable zinc.

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