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Valeriy G. Ostapchenko, Flavio H. Beraldo, Andre L. S. Guimarães, Sanju Mishra, Monica Guzman, Jue Fan, Vilma R. Martins, Vania F. Prado and Marco A. M. Prado Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease Journal of Neurochemistry 127

Version of Record online: 27 MAY 2013 | DOI: 10.1111/jnc.12296

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Prion protein (PrPC) and metabotropic glutamate receptors (mGluR) are implicated in Alzheimer's disease (AD). We found age-dependent increase in PrPC processing, ADAM10 and mGluR1 levels in AD mouse model. These changes could be reproduced in cultured cortical neurons treated with Aβ peptide. Our findings suggest that increased levels of Aβ can trigger compensatory responses that may affect neuronal toxicity.

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