Pingfang Song, Stephen S. Rekow, Corey-Ayne Singleton, Harmanjatinder S. Sekhon, Gregory A. Dissen, Minerva Zhou, Barbara Campling, Jon Lindstrom and Eliot R. Spindel Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis Journal of Neurochemistry 126
It is now well established that many non-neuronal cell types synthesize and secrete acetylcholine that acts as an autocrine or paracrine hormone. Although there are many similarities between neuronal and non-neuronal acetylcholine synthesis, there is a difference in choline transport for acetylcholine synthesis. Neurons must use the high affinity choline transporter CHT1, but many non-neuronal cells synthesize acetylcholine without CHT1. In this article, we show that non-neuronal cells utilize the choline transporter-like protein-4 (CTL4) for ACh synthesis.
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