Suhail Rasool, Hilda Martinez-Coria, Jessica W. Wu, Frank LaFerla and Charles G. Glabe Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice Journal of Neurochemistry 126
We studied effect of immunotherapy of two sequence-independent non-fibrillar oligomer specific monoclonal antibodies on the cognitive function, amyloid load, and tau pathology in 3xTg-AD mice. Passive immunization with anti-oligomeric monoclonal antibodies effectively attenuates cognitive and pathological impairments in 3xTg-AD mice. These findings demonstrate the potential of using oligomer specific monoclonal antibodies as a therapeutic approach to prevent and treat Alzheimer's disease.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf