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Suhail Rasool, Hilda Martinez-Coria, Jessica W. Wu, Frank LaFerla and Charles G. Glabe Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice Journal of Neurochemistry 126

Article first published online: 16 JUN 2013 | DOI: 10.1111/jnc.12305

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We studied effect of immunotherapy of two sequence-independent non-fibrillar oligomer specific monoclonal antibodies on the cognitive function, amyloid load, and tau pathology in 3xTg-AD mice. Passive immunization with anti-oligomeric monoclonal antibodies effectively attenuates cognitive and pathological impairments in 3xTg-AD mice. These findings demonstrate the potential of using oligomer specific monoclonal antibodies as a therapeutic approach to prevent and treat Alzheimer's disease.

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