Abu Syed Md Anisuzzaman, Junsuke Uwada, Takayoshi Masuoka, Hatsumi Yoshiki, Matomo Nishio, Yuji Ikegaya, Naoya Takahashi, Norio Matsuki, Yasuhisa Fujibayashi, Yoshiharu Yonekura, Toshihiko Momiyama and Ikunobu Muramatsu Novel contribution of cell surface and intracellular M1-muscarinic acetylcholine receptors to synaptic plasticity in hippocampus Journal of Neurochemistry 126
Version of Record online: 9 JUN 2013 | DOI: 10.1111/jnc.12306
M1 muscarinic acetylcholine receptors (M1-mAChRs) are G-protein coupled receptors which predominantly exist in the brain and are involved in cognitive enhancement. In this issue, we found that M1-mAChRs occur not only at synaptic and extrasynaptic surface membrane but also at intracellular sites in hippocampal pyramidal neurons, and may facilitate long-term potentiation (LTP) with distinct signal cascades and on distinct timescales.
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