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Kumud Kunjilwar, Yan Qian and Paul J. Pfaffinger Functional stoichiometry underlying KChIP regulation of Kv4.2 functional expression Journal of Neurochemistry 126

Version of Record online: 9 JUN 2013 | DOI: 10.1111/jnc.12309

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Mutations to the Kv4.2 potassium channel that disrupt KChIP binding act as dominant negative mutants to trap channels in intracellular membranes. This effect is due to the exposure of an N-terminal regulatory sequence (FERN, blue) on the potassium channel, and can be eliminated when this sequence is deleted.

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