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Yuniesky Andrade-Talavera, Paloma Duque-Feria, Talvinder S. Sihra and Antonio Rodríguez-Moreno Pre-synaptic kainate receptor-mediated facilitation of glutamate release involves PKA and Ca2+-calmodulin at thalamocortical synapses Journal of Neurochemistry 126

Version of Record online: 11 JUN 2013 | DOI: 10.1111/jnc.12310

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Ca2+/calmodulin involvement in pre-synaptic kainate receptors facilitation of glutamate release at thalamocortical synapses. We determined the mechanism by which kainate receptors (KARs) mediate a facilitation of glutamate release at thalamo-L4 cortical cell synapses. We find that an increase in cytosolic Ca2+ concentration, contingent on extra- and intra-cellular sources, in the pre-synaptic thalamic neuron, operates through the formation of Ca2+-calmodulin complexes to activate an AC/cAMP/PKA signalling pathway. This action of KARs may support learning and memory processes.

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