Caitlin A. Massey, Gloria Kim, Andrea E. Corcoran, Robin L. Haynes, David S. Paterson, Kevin J. Cummings, Susan M. Dymecki, George B. Richerson, Eugene E. Nattie, Hannah C. Kinney and Kathryn G. Commons Development of brainstem 5-HT1A receptor-binding sites in serotonin-deficient mice Journal of Neurochemistry 126
To elucidate the developmental relationship between serotonin (5-HT) levels and 5-HT1A receptors in the brainstem, we examined 5-HT1A binding in two 5-HT-deficient mouse models. In nuclei containing 5-HT neurons, 5-HT1A binding was decreased (autoreceptors), while binding was maintained in projection sites (heteroreceptors). Thus, brainstem 5-HT1A-heteroreceptor-binding sites do not appear developmentally sensitive to reduced brain 5-HT levels.
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