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Paige Beck, Susan Mahaffey, Francisco J. Urbano and Edgar Garcia-Rill Role of G-proteins in the effects of leptin on pedunculopontine nucleus neurons Journal of Neurochemistry 126

Article first published online: 12 JUN 2013 | DOI: 10.1111/jnc.12312

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Beck et al. investigated the effects of leptin on the intrinsic properties of neurons from the pedunculopontine nucleus (PPN). Leptin reduced the amplitude of voltage-gated sodium (INa) and hyperpolarization-activated cyclic nucleotide-gated HCN (IH) channels. These effects were antagonized by a leptin receptor (OB-R) antagonist and by the G-protein antagonist GDPβ.

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