Paige Beck, Susan Mahaffey, Francisco J. Urbano and Edgar Garcia-Rill Role of G-proteins in the effects of leptin on pedunculopontine nucleus neurons Journal of Neurochemistry 126
Beck et al. investigated the effects of leptin on the intrinsic properties of neurons from the pedunculopontine nucleus (PPN). Leptin reduced the amplitude of voltage-gated sodium (INa) and hyperpolarization-activated cyclic nucleotide-gated HCN (IH) channels. These effects were antagonized by a leptin receptor (OB-R) antagonist and by the G-protein antagonist GDPβ.
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