Chengren Li, Teng Guan, Xueping Chen, Wenyan Li, Qiyan Cai, Jianqin Niu, Lan Xiao and Jiming Kong BNIP3 mediates pre-myelinating oligodendrocyte cell death in hypoxia and ischemia Journal of Neurochemistry 127
Pre-myelinating oligodendrocytes (preOLs) are known to be highly vulnerable to ischemic insults. It remains unclear, however, how preOLs die. This study shows that BNIP3, a proapoptotic member of the Bcl-2 family proteins, is a mediator of hypoxia/ischemia-induced preOLs death. The BNIP3 cell death pathway may therefore be a new target for protecting oligodendrocytes from death after stroke.
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