Joydip Das, Shiyu Xu, Satyabrata Pany, Ashley Guillory, Vrutant Shah and Gregg W. Roman The pre-synaptic Munc13-1 binds alcohol and modulates alcohol self-administration in Drosophila Journal of Neurochemistry 126
The pre-synaptic Mun13-1 protein is a critical regulator of synaptic vesicle fusion and may be involved in processes that lead to ethanol abuse and addiction. We studied its interaction with alcohol and identified Glu-582 as a critical residue for ethanol binding. Munc13-1 can functionally complement the Dunc13 haploinsufficient ethanol self-administration phenotype in Drosophila melanogaster, indicating that this protein participates in alcohol-induced behavioral plasticity.
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