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Ana C. Andreazza, Jun-Feng Wang, Faraz Salmasi, Li Shao and Lionel T. Young Specific subcellular changes in oxidative stress in prefrontal cortex from patients with bipolar disorder Journal of Neurochemistry 127

Article first published online: 11 JUN 2013 | DOI: 10.1111/jnc.12316

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Oxidative stress has been shown to be higher in the brain of patients with bipolar disorder (BD). Here, we demonstrated increased levels of protein oxidation in synaptosomes from postmortem prefrontal cortex from patients from BD group, while 3-nitrotyrosine was increased in mitochondria from BD and schizophrenia (SCZ) groups. Moreover, lipid peroxidation was found increased in the BD when compared with controls; suggesting that in BD mitochondrial proteins are more susceptible to potentially reversible nitrosative damage while more longstanding oxidative damage occurs to synaptic proteins.

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