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Min-Young Noh, Seong H. Koh, Sung-Min Kim, Tangui Maurice, Sae-Kwang Ku and Seung H. Kim Neuroprotective effects of donepezil against Aβ42-induced neuronal toxicity are mediated through not only enhancing PP2A activity but also regulating GSK-3β and nAChRs activity Journal of Neurochemistry 127

Version of Record online: 17 JUN 2013 | DOI: 10.1111/jnc.12319

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We investigated neuroprotective mechanisms of donepezil against Aβ42 toxicity: Donepezil increased neuronal viability with reduced p-tau by enhancing PP2A activity. Despite of blocked PP2A activity, donepezil showed additional recovering effect on neuronal viability, which findings led us to assume that additional mechanisms of donepezil including its inhibitory effect on GSK-3β activity and activating role of nicotinic AChRs might be involved.

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