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Joanna Gruszczynska-Biegala and Jacek Kuznicki Native STIM2 and ORAI1 proteins form a calcium-sensitive and thapsigargin-insensitive complex in cortical neurons Journal of Neurochemistry 126

Version of Record online: 12 JUN 2013 | DOI: 10.1111/jnc.12320

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We show in neuronal somata the formation of endogenous complexes of stromal interaction molecule 2 (STIM2) with ORAI1 calcium channels. Their number increased when intracellular Ca2+ concentrations were decreased by the Ca2+ chelator BAPTA-AM or a low-calcium medium (EGTA), but did not in the presence of thapsigargin (TG). We conclude that the small drop of Ca2+ level in endoplasmic reticulum, due to the decreased level of intracellular Ca2+, is sufficient to trigger STIM2-ORAI1 complex formation in a thapsigargin-insensitive manner.

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