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Amy A. Herrold, Amanda L. Persons and T. Celeste Napier Cellular distribution of AMPA receptor subunits and mGlu5 following acute and repeated administration of morphine or methamphetamine Journal of Neurochemistry 126

Article first published online: 18 JUN 2013 | DOI: 10.1111/jnc.12323

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Chronic methamphetamine results in glutamate release and synaptic plasticity, likely involving AMPA receptors. Metabotropic glutamate receptor group 1 subtype 5 (mGlu5) activates striatal-enriched tyrosine phosphatase isoform 61 (STEP61) to internalize AMPARs. We reveal that repeated methamphetamine increased cell surface AMPAR subunits and decreased STEP61 levels in rat cortex; this change was not seen after mGlu5 antagonist treatment.

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