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Tharine Dal-Cim, Fabiana K. Ludka, Wagner C. Martins, Charlise Reginato, Esther Parada, Javier Egea, Manuela G. López and Carla I. Tasca Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions Journal of Neurochemistry 126

Article first published online: 17 JUN 2013 | DOI: 10.1111/jnc.12324

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Guanosine (GUO) promotes neuroprotection against oxygen and glucose deprivation in hippocampal slices via a mechanism that involves modulation of adenosine receptors and activation of PI3K/AKT and MAPK/ERK. These signaling pathways are implicated in the prevention of mitochondrial membrane depolarization, reduction of oxidative stress, regulation of inflammation by inhibition of NF-κB and inducible nitric oxide synthase (iNOS), and the promotion of glutamate uptake. EAAT: excitatory amino acid transporter, ROS: reactive oxygen species.

Read the Editorial Highlight for this article on doi: 10.1111/jnc.12328.

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