E-mail a Wiley Online Library Link

Noriko Himori, Kotaro Yamamoto, Kazuichi Maruyama, Morin Ryu, Keiko Taguchi, Masayuki Yamamoto and Toru Nakazawa Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death Journal of Neurochemistry 127

Version of Record online: 17 JUN 2013 | DOI: 10.1111/jnc.12325

Thumbnail image of graphical abstract

This study suggests that NF-E2 related factor 2 (Nrf2), a transcription factor, plays a pivotal role in counteracting oxidative stress. Most importantly, a neuroprotective effect against oxidative stress-induced retinal ganglion cell (RGC) death was achieved with the pharmacological Nrf2 activator CDDO-Im. This suggests that pharmacological treatment to up-regulate Nrf2 signaling may be a new therapeutic technique to protect RGCs.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field