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Noriko Himori, Kotaro Yamamoto, Kazuichi Maruyama, Morin Ryu, Keiko Taguchi, Masayuki Yamamoto and Toru Nakazawa Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death Journal of Neurochemistry 127

Version of Record online: 17 JUN 2013 | DOI: 10.1111/jnc.12325

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This study suggests that NF-E2 related factor 2 (Nrf2), a transcription factor, plays a pivotal role in counteracting oxidative stress. Most importantly, a neuroprotective effect against oxidative stress-induced retinal ganglion cell (RGC) death was achieved with the pharmacological Nrf2 activator CDDO-Im. This suggests that pharmacological treatment to up-regulate Nrf2 signaling may be a new therapeutic technique to protect RGCs.

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