E-mail a Wiley Online Library Link

Mayumi Akizuki, Hirofumi Yamashita, Kengo Uemura, Hirofumi Maruyama, Hideshi Kawakami, Hidefumi Ito and Ryosuke Takahashi Optineurin suppression causes neuronal cell death via NF-κB pathway Journal of Neurochemistry 126

Article first published online: 17 JUN 2013 | DOI: 10.1111/jnc.12326

Thumbnail image of graphical abstract

Among the genes for typical amyotrophic lateral sclerosis (ALS) phenotypes, optineurin (OPTN) is virtually the only gene in which a loss-of-function mutation is considered as the principal disease mechanism. We found that OPTN knockdown induced neuronal cell death via NF-κB activation. Furthermore, proapoptotic molecules such as p53 and Bax representing downstream targets of NF-κB are suggested to be involved in neuronal death.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field