Michael E. Cahill, Christine Remmers, Kelly A. Jones, Zhong Xie, Robert A. Sweet and Peter Penzes Neuregulin1 signaling promotes dendritic spine growth through kalirin Journal of Neurochemistry 126
NRG1 and erbB4 increase spine size, while NRG1 activity, but not erbB4 activity, increases spine density. NRG1 also increases spine GluA1 content, and the GEF kalirin is necessary for the ability of NRG1 and erbB4 to regulate spine morphogenesis. We find that environmental enrichment, which is known to stimulate spine morphogenesis in the forebrain, increases cortical and hippocampal erbB4 expression.
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