Xinni Luo, Le Hou, Haishan Shi, Xiaomei Zhong, Yufeng Zhang, Dong Zheng, Yan Tan, Guoyan Hu, Nan Mu, Jianping Chan, Xinru Chen, Yaxiu Fang, Fengchun Wu, Hongbo He and Yuping Ning CSF levels of the neuronal injury biomarker visinin-like protein-1 in Alzheimer's disease and dementia with Lewy bodies Journal of Neurochemistry 127
Article first published online: 26 JUN 2013 | DOI: 10.1111/jnc.12331
Neuronal Ca2+-sensor protein VILIP-1 has been implicated in the calcium-mediated neuronal injury and pathological change of AD. The CSF VILIP-1 and VILIP-1/Aβ1-42 levels had enough diagnostic accuracy to allow the detection and differential diagnosis of AD. CSF VILIP-1 is a useful biomarker for AD. Evaluating the CSF levels of VILIP-1 in AD and DLB patients could facilitate clinical diagnosis.
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