Ramune Morkuniene, Aurelija Zvirbliene, Indre Dalgediene, Paulius Cizas, Silvija Jankeviciute, Giedre Baliutyte, Ramunas Jokubka, Marija Jankunec, Gintaras Valincius and Vilmante Borutaite Antibodies bound to Aβ oligomers potentiate the neurotoxicity of Aβ by activating microglia Journal of Neurochemistry 126
Immunization against Aβ in Alzheimer's disease carries a significant risk of neuroinflammation, the mechanisms of which are poorly understood. In this study we show that oligomeric antigens such as Aβ and viral proteins complexed with their specific antibodies can exert neurotoxic effects by Fc-dependent microglia activation. This suggests that therapies using antibodies against oligomeric proteins should be used with caution.
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