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João M. N. Duarte and Rolf Gruetter Glutamatergic and GABAergic energy metabolism measured in the rat brain by 13C NMR spectroscopy at 14.1 T Journal of Neurochemistry 126

Article first published online: 27 JUN 2013 | DOI: 10.1111/jnc.12333

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We performed 13C NMR spectroscopy in vivo at high magnetic field (14.1 T) upon administration of [1,6-13C]glucose. This allowed to measure 13C incorporation into the three aliphatic carbons of GABA in the rat brain, in addition to those of glutamate, glutamine and aspartate. These data were then modelled to determine fluxes of energy metabolism in GABAergic and glutamatergic neurons and glial cells.

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