Susan A. Austin, Anantha V. Santhanam, David J. Hinton, Doo-Sup Choi and Zvonimir S. Katusic Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology Journal of Neurochemistry 127
Cardiovascular risk factors are associated with increased incidence of Alzheimer's disease (AD). A common feature of these risk factors is decreased endothelial nitric oxide (NO). We observed, in mice deficient in endothelial nitric oxide synthase, increased amyloid precursor protein (APP), β-site APP cleaving enzyme 1, amyloid beta levels, microglial activation, and impaired spatial memory. This suggests chronic loss of endothelial NO may be an important contributor to the pathogenesis of sporadic AD.
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