Myrthe Rouwette, Jean-Paul Noben, Jack Van Horssen, Bart Van Wijmeersch, Raymond Hupperts, Peter J. Jongen, Marcel M. Verbeek, Peter P. De Deyn, Piet Stinissen and Veerle Somers Identification of coronin-1a as a novel antibody target for clinically isolated syndrome and multiple sclerosis Journal of Neurochemistry 126
Recently, we identified the mimotope UH-CIS6 as a novel antibody target for clinically isolated syndrome (CIS) and relapsing-remitting multiple sclerosis (RR-MS). By using a peptide ELISA, we detected a significantly increased frequency of anti-UH-CIS6 antibody reactivity in cerebrospinal fluid samples from CIS and RR-MS patients as compared with controls. Coronin-1a was identified and confirmed as the in vivo antibody target for UH-CIS6. Furthermore, coronin-1a was expressed by T cells and macrophages in MS brain. Together, our results demonstrate that coronin-1a is a novel antibody target for CIS and MS.
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