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Ryotaro Saiki, Daisuke Hayashi, Yukiko Ikuo, Kazuhiro Nishimura, Itsuko Ishii, Kaoru Kobayashi, Kan Chiba, Toshihiko Toida, Keiko Kashiwagi and Kazuei Igarashi Acrolein stimulates the synthesis of IL-6 and C-reactive protein (CRP) in thrombosis model mice and cultured cells Journal of Neurochemistry 127

Version of Record online: 1 JUL 2013 | DOI: 10.1111/jnc.12336

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The combined measurements of protein-conjugated acrolein (PC-Acro), IL-6, and C-reactive protein (CRP) in plasma were useful for identifying silent brain infarction. The aim of this study was to determine whether acrolein causes increased production of IL-6 and CRP, and indeed acrolein increased IL-6 synthesis and IL-6 in turn increased CRP synthesis. Furthermore, IL-6 decreased acrolein toxicity in several cell lines.

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