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Irene L. Llorente, Taiana C. Burgin, Diego Pérez-Rodríguez, Beatriz Martínez-Villayandre, Carlos C. Pérez-García and Arsenio Fernández-López Unfolded protein response to global ischemia following 48 h of reperfusion in the rat brain: the effect of age and meloxicam Journal of Neurochemistry 127

Version of Record online: 4 JUL 2013 | DOI: 10.1111/jnc.12337

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In this study, we conclude that the unfolded protein response (UPR) to ischemic/reperfusion insult is age- and probably inflammation-dependent and could play an important role in ischemic vulnerability. The UPR strongly decreased in aged rats, suggesting a reduced ability for cell survival. The increase in the mRNA levels of UPR gene transcripts in 3-month-old animals was abolished or even reverted by treatment with meloxicam, an anti-inflammatory agent.

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