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Yanxin Zhao, Fangzhe Chen, Shufen Chen, Xueyuan Liu, Mei Cui and Qiang Dong The Parkinson's disease-associated gene PINK1 protects neurons from ischemic damage by decreasing mitochondrial translocation of the fission promoter Drp1 Journal of Neurochemistry 127

Article first published online: 30 JUN 2013 | DOI: 10.1111/jnc.12340

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In this study by employing an oxygen–glucose deprivation (OGD) neuronal model, we explored the function of PINK1 in cerebral ischemia. We indicated that PINK1 significantly ameliorated OGD induced cell death and energy disturbance including reduced ATP generation and collapse of mitochondrial membrane potential by attenuating mitochondrial translocation of Drp1, which maintains mitochondrial function and inhibits ischemia-induced mitochondrial fission.

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