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Rong Xie, Peng Wang, Xunming Ji and Heng Zhao Ischemic post-conditioning facilitates brain recovery after stroke by promoting Akt/mTOR activity in nude rats Journal of Neurochemistry 127

Article first published online: 8 JUL 2013 | DOI: 10.1111/jnc.12342

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Post-conditioning did not attenuate infarction in nude rats measured 2 days post-stroke, but improved neurological function in nude rats and reduced brain damage 30 days after stroke. It resulted in increased-activities of Akt and mTOR, S6K and p-4EBP1. The mTOR inhibitor rapamycin abolished the long-term protective effects of IPostC.

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