Gary N. Y. Chan, Victor Saldivia, Yingbo Yang, Henrianna Pang, Inés de Lannoy and Reina Bendayan In vivo induction of P-glycoprotein expression at the mouse blood–brain barrier: an intracerebral microdialysis study Journal of Neurochemistry 127
Applying microdialysis, distribution of quinidine, a P-gp substrate, in mouse brain extracellular fluid (ECF) was investigated following ligand-mediated P-glycoprotein (P-gp) induction at the blood–brain barrier (BBB). We demonstrated that a PXR agonist (dexamethasone) significantly up-regulated P-gp in brain capillaries and reduced quinidine brain ECF concentrations. Our data suggest that drug–drug interactions as a result of P-gp induction at the BBB are possible.
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