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David S. Goldstein, Patti Sullivan, Courtney Holmes, Gary W. Miller, Shawn Alter, Randy Strong, Deborah C. Mash, Irwin J. Kopin and Yehonatan Sharabi Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease Journal of Neurochemistry 126

Article first published online: 22 JUL 2013 | DOI: 10.1111/jnc.12345

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According to the ‘catecholaldehyde hypothesis,’ the toxic dopamine metabolite DOPAL contributes to loss of striatal dopaminergic innervation in Parkinson's disease. Here we provide post-mortem neurochemical evidence that in Parkinson's disease patients, putamen DOPAL buildup reflects decreased vesicular sequestration of cytosolic dopamine and decreased DOPAL metabolism by aldehyde dehydrogenase. The results fit with an intra-neuronal autotoxic mechanism of Parkinson's disease.

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