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Paola Conforti, Chiara Zuccato, Germano Gaudenzi, Alessandro Ieraci, Stefano Camnasio, Noel J. Buckley, Cesare Mutti, Franco Cotelli, Alessandro Contini and Elena Cattaneo Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models Journal of Neurochemistry 127

Version of Record online: 19 JUL 2013 | DOI: 10.1111/jnc.12348

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Dysregulation of REST and its target genes have been implicated in Huntington's disease. We have coupled structured-based virtual screening approaches to biological assays and selected molecules that interfere with the repressor complex REST-mSIN3b. In particular, at the non-toxic dose, compound C91 is able to increase neuronal gene transcription and to reverse low Bdnf mRNA levels in HD models.

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