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Gelareh Mazarei, David P. Budac, Ge Lu, Hans Adomat, Emma S. Tomlinson Guns, Thomas Möller and Blair R. Leavitt Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease Journal of Neurochemistry 127

Article first published online: 14 JUL 2013 | DOI: 10.1111/jnc.12350

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We propose that induction of indoleamine 2,3 dioxygenase (Ido1) expression and activity in the striatum by mutant huntingtin (mHTT) plays a central role in the observed imbalance of downstream kynurenine (Kyn) pathway metabolites. This imbalance, and altered transport of kynurenine pathway metabolites through the blood brain barrier (BBB) from blood to CNS, may result in increased sensitivity of striatal neurons to glutamate toxicity in Huntington disease.

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