Giannina Descalzi, Tao Chen, Kohei Koga, Xiang-Yao Li, Kaori Yamada and Min Zhuo Cortical GluK1 kainate receptors modulate scratching in adult mice Journal of Neurochemistry 126
Cortical contribution to pruritogen-induced scratching is shown in an animal model. Through a combination of pharmacological, genetic, and electrophysiological data, we show that cortical GluK1-containing kainate receptors (KAR) are involved in pruritogen-induced scratching. Peripheral application of itching stimuli activates excitatory afferents projecting to ACC layer II/III pyramidal neurons, initiating presynaptic glutamate (Glu) release which activates postsynaptic AMPA receptors. Simultaneously, presynaptic Glu activates presynaptic KAR located on inhibitory neurons, thereby modulating evoked GABA release and affecting the attenuation of the postsynaptic response.
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