Muhammad N. Ashraf, Cezar Gavrilovici, Syed U. Ali Shah, Farzana Shaheen, Muhammad I. Choudhary, Atta-ur Rahman, Margaret Fahnestock, Shabana U. Simjee and Michael O. Poulter A novel anticonvulsant modulates voltage-gated sodium channel inactivation and prevents kindling-induced seizures Journal of Neurochemistry 126
Isoxylitones, isolated from Delphinium denudatum root prevent seizure induction. Activity was tested on voltage-gated sodium channels (VGSCs) in both cultured neurons and brain slices isolated from controls and rats with experimental epilepsy (kindling model). Isoxylitones enhanced sodium channel inactivation with an IC50 of about 200 nM. Our findings suggest isoxylitones as a potential novel anticonvulsant agent.
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