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Pietro Farinelli, Blanca Arango-Gonzalez, Jakob Völkl, Ioana Alesutan, Florian Lang, Eberhart Zrenner, François Paquet-Durand and Per A.R. Ekström Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors Journal of Neurochemistry 127

Article first published online: 22 JUL 2013 | DOI: 10.1111/jnc.12353

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Retinitis Pigmentosa (RP) involves a hereditary degeneration of photoreceptors. Here, we demonstrate an over-expression of the anti-ageing protein Klotho in several rodent Retinitis Pigmentosa models. The over-expression of the protein is also shown to be linked to the degeneration of photoreceptors. In summary, our work suggests Klotho as a novel player in the retina, with a clear connection to photoreceptor cell death as well as with an influence on retinal organization.

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