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Linjing Mu, Daniel Bieri, Roger Slavik, Konstantin Drandarov, Adrienne Müller, Stjepko Čermak, Markus Weber, Roger Schibli, Stefanie D. Krämer and Simon M. Ametamey Radiolabeling and in vitro /in vivo evaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor Journal of Neurochemistry 126

Version of Record online: 19 JUL 2013 | DOI: 10.1111/jnc.12354

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The cannabinoid type 2 receptor (CB2) plays an important role in neuroinflammatory and neuro–degenerative diseases. [11C]KD2, a new CB2 radioligand, exhibits selectivity towards CB2 receptor in vitro and in vivo in rat. A pilot autoradiography study with spinal cord slices from amyotrophic lateral sclerosis patients with [11C]KD2 suggested the presence of CB2 under disease conditions (Figure). Selective CB2 agonist, GW405833.

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