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G. Cristina Brailoiu, Elena Deliu, Andrei A. Tica, Joseph E. Rabinowitz, Douglas G. Tilley, Khalid Benamar, Walter J. Koch and Eugen Brailoiu Nesfatin-1 activates cardiac vagal neurons of nucleus ambiguus and elicits bradycardia in conscious rats Journal of Neurochemistry 126

Article first published online: 19 JUL 2013 | DOI: 10.1111/jnc.12355

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Our results indicate that nesfatin-1, one of the most potent feeding peptides, increases cytosolic Ca2+ by promoting Ca2+ influx via P/Q channels and depolarizes nucleus ambiguus neurons; both effects are Gi/o-mediated. In vivo studies indicate that microinjection of nesfatin-1 into nucleus ambiguus produces bradycardia in conscious rats. This is the first report that nesfatin-1 increases the parasympathetic cardiac tone.

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