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Jeremy Celver, Meenakshi Sharma, Vaidehi Thanawala, J. Christopher Octeau and Abraham Kovoor Arrestin-dependent but G-protein coupled receptor kinase-independent uncoupling of D2-dopamine receptors Journal of Neurochemistry 127

Version of Record online: 29 JUL 2013 | DOI: 10.1111/jnc.12359

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The classical model for the uncoupling and desensitization of G-protein coupled receptors (GPCRs) involves the phosphorylation of the agonist-bound receptor by G protein coupled receptor kinases (GRK), followed by the binding of arrestin to the GRK phosphorylated agonist-activated receptor. We reconstituted D2-dopamine receptor (D2R) signaling in Xenopus oocytes to show that arrestin-mediated uncoupling of D2R from associated G proteins (Gαβγ) occurs independently of GRKs.

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