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Yuta Ishizuka, Naomasa Kakiya, Lee A. Witters, Noriko Oshiro, Tomoaki Shirao, Hiroyuki Nawa and Nobuyuki Takei AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons Journal of Neurochemistry 127

Article first published online: 29 JUL 2013 | DOI: 10.1111/jnc.12362

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Here, we report that growth factor-induced mTORC1 activity is dependent on glucose sufficiency, but not on amino acids in neurons. The mechanism underlying this phenomenon is AMP-activated protein kinase (AMPK) activation. AMPK activation inhibits BDNF-induced mTORC1 activity through TSC2 and raptor.

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