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Hector J. Monzo, Thomas I. H. Park, Birger V. Dieriks, Deidre Jansson, Richard L. M. Faull, Mike Dragunow and Maurice A. Curtis Insulin and IGF1 modulate turnover of polysialylated neural cell adhesion molecule (PSA–NCAM) in a process involving specific extracellular matrix components Journal of Neurochemistry 126

Version of Record online: 5 AUG 2013 | DOI: 10.1111/jnc.12363

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Neural cell adhesion molecules (NCAMs) are critically involved in cell differentiation and migration. Polysialylation (PSA)/desialylation of NCAMs switches their functional interaction mode and, in turn, migration and differentiation. We have found that the desialylation process of PSA–NCAM occurs via endocytosis, induced by collagen-IV and blocked by insulin-like growth factor (IGF1) and insulin, suggesting a novel association between PSA–NCAM, IGF1/insulin and brain/tumour plasticity.

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