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Jong Seong Ha, Ki-Sun Kwon and Sung Sup Park PI3Kγ contributes to MEK1/2 activation in oxidative glutamate toxicity via PDK1 Journal of Neurochemistry 127

Version of Record online: 4 AUG 2013 | DOI: 10.1111/jnc.12364

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Glutamate induces extracellular H2O2 generation by NADPH oxidase 4 (Nox4), leading to cell death in neurons. Our experiments, using siRNAs and chemical inhibitors, showed the PI3Kγ-PDK1-MEK axis but not Akt1, mTOR, or S6K to be involved in the glutamate-induced H2O2 generation and the subsequent toxicity in neurons.

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