E-mail

E-mail a Wiley Online Library Link

Jong Seong Ha, Ki-Sun Kwon and Sung Sup Park PI3Kγ contributes to MEK1/2 activation in oxidative glutamate toxicity via PDK1 Journal of Neurochemistry 127

Article first published online: 4 AUG 2013 | DOI: 10.1111/jnc.12364

Thumbnail image of graphical abstract

Glutamate induces extracellular H2O2 generation by NADPH oxidase 4 (Nox4), leading to cell death in neurons. Our experiments, using siRNAs and chemical inhibitors, showed the PI3Kγ-PDK1-MEK axis but not Akt1, mTOR, or S6K to be involved in the glutamate-induced H2O2 generation and the subsequent toxicity in neurons.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH