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Martin Göttle, Heike Burhenne, Diane Sutcliffe and H. A. Jinnah Purine metabolism during neuronal differentiation: the relevance of purine synthesis and recycling Journal of Neurochemistry 127

Article first published online: 18 AUG 2013 | DOI: 10.1111/jnc.12366

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Differentiation of dopaminergic PC6-3 cells is accompanied by increased purine pools and energy state. The lack of a functional purine recycling pathway causes purine limitation in both undifferentiated and differentiated cells, as well as profound loss of dopamine content. The results imply an unknown mechanism by which intracellular purine levels regulate dopamine levels.

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