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Hua Cheng, Miao Wang, Jian-Liang Li, Nigel J. Cairns and Xianlin Han Specific changes of sulfatide levels in individuals with pre-clinical Alzheimer's disease: an early event in disease pathogenesis Journal of Neurochemistry 127

Version of Record online: 29 JUL 2013 | DOI: 10.1111/jnc.12368

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To determine lipid changes at the stage of pre-clinical Alzheimer's disease (AD) (i.e., cognitively normal at death, but with AD neuropathology), we performed lipidomics analysis and found that sulfatide levels were significantly lower in subjects with pre-clinical AD compared to those without AD neuropathology. The results suggest that sulfatide loss is among the earliest events of AD development.

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