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Yang Liu, Zhao Zhao, Fan Yang, Yimei Gao, Jian Song and Yu Wan microRNA-181a is involved in insulin-like growth factor-1-mediated regulation of the transcription factor CREB1 Journal of Neurochemistry 126

Version of Record online: 6 AUG 2013 | DOI: 10.1111/jnc.12370

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microRNAs (miRNAs) regulate gene expression at the post-transcriptional level and are involved in the central nervous system development. Here, we demonstrate that miR-181a can inhibit the expression of the transcription factor CREB1 by specifically targeting its mRNA 3′UTR and inhibit the development of hippocampus neurons. Repressed expression of miR-181a is involved in IGF-1-mediated up-regulation of CREB1 in vivo and in vitro. These findings indicate that miR-181a could be a potential target for preventing neurodegenerative diseases.

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