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Fabian Runkel, Astrid Rohlmann, Carsten Reissner, Stefan-Martin Brand and Markus Missler Promoter-like sequences regulating transcriptional activity in neurexin and neuroligin genes Journal of Neurochemistry 127

Article first published online: 20 AUG 2013 | DOI: 10.1111/jnc.12372

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Neurexins and neuroligins constitute large families of synaptic cell-surface molecules that play essential roles in neurotransmission and are linked to autism spectrum disorders and schizophrenia. To better understand their gene regulation, we analyze putative promoter regions for transcriptional activity. Expression involves the brain-specific regulator MeCP2 and methylation frequency, suggesting an unexpected pathway for regulating their distribution, splicing or activity-dependent plasticity.

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