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Andrew C. Meyer, Nichole M. Neugebauer, Guangrong Zheng, Peter A. Crooks, Linda P. Dwoskin and Michael T. Bardo Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo Journal of Neurochemistry 127

Version of Record online: 20 AUG 2013 | DOI: 10.1111/jnc.12373

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We determined if inhibition of the vesicular monoamine transporter (VMAT2) alters METH-induced changes in dopamine (DA) release, metabolism, and synthesis in vivo. Our results suggest that selective inhibition of VMAT2 produces a time-dependent decrease in DA release as a result of alterations in tyrosine hydroxylase (TH) activity, which may play a role in the ability of the VMAT2 inhibitor GZ-793A to decrease METH reward.

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