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Supriti Samantaray, Varduhi H. Knaryan, Donald C. Shields and Naren L. Banik Critical role of calpain in spinal cord degeneration in Parkinson's disease Journal of Neurochemistry 127

Article first published online: 20 AUG 2013 | DOI: 10.1111/jnc.12374

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We proposed calpain over-activation and calpain-calpastatin dysregulation driving in a cascade of inflammatory responses (microglial activation and T cell infiltration) and degenerative pathways culminating in axonal degeneration and neuronal death in spinal cord of Parkinson's disease patients. This may be one of the crucial mechanisms in the degenerative process.

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