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Sarah J. Bertrand, Charles F. Mactutus, Marina V. Aksenova, Tori D. Espensen-Sturges and Rosemarie M. Booze Synaptodendritic recovery following HIV Tat exposure: Neurorestoration by phytoestrogens Journal of Neurochemistry 128

Version of Record online: 26 AUG 2013 | DOI: 10.1111/jnc.12375

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The HIV-1 transactivating protein (Tat) is produced during viral latency in the brain. Treatment with either daidzein or liquiritigenin restored the loss of synaptic connectivity produced by HIV-1 Tat. This neurorestoration was mediated by estrogen receptors (ER). These results suggest that plant-derived phytoestrogens may promote recovery from HIV-1-induced synaptodendritic damage.

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