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Jeanine H. Heiser, Anita M. Schuwald, Giacomo Sillani, Lian Ye, Walter E. Müller and Kristina Leuner TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling Journal of Neurochemistry 127

Article first published online: 19 AUG 2013 | DOI: 10.1111/jnc.12376

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Alterations in synaptic plasticity are considered to play an important role in the pathogenesis of depression. Beside several other proteins, TRPC6 channels regulate synaptic plasticity. This study demonstrates that different pathways including Ras/MEK/ERK, PI3K/Akt, and CAMKIV are involved in the improvement of synaptic plasticity by the TRPC6 activator hyperforin, the antidepressant active constituent of St. John's wort extract.

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